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pentobarbital will lessen the extent or outcome of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Strong or average CYP3A inducers may well lower cobimetinib systemic publicity by >eighty% and lessen its efficacy.pentobarbital will lessen the level or result of buprenorphine b